Design, Development, Physicochemical and In Vitro Evaluation of Transdermal Patches Containing Verapamil Hydrochloride in Ethyl Cellulose -Povidone Matrices

An attempt has been made to develop transdermal patches of Verapamil HCI by using ethyl cellulose and polyvinyl pyrrolidoneK30 as polymer matrix, dibutyl phthalate as plasticiser and polyvinyl alcohol as backing membrane. The present study has revealed the designing and in vitro evaluation of transdermal patches containing verapamil hydrochloride in ethyl cellulose -povidone matrices. After preparation of patches several physicochemical properties were examined i.e. thickness, percent moisture content, percent moisture uptake, percent flatness, water vapour transmission rate, tensile strength and weight variation to satisfy the suitable criteria's. In vitro skin permeation study was performed taking rat skin using modified Keshary -Chien diffusion cell. After the graphical examination conclusion was drawn that in formulation with higher concentration of hydrophobic polymer, patches releases drug extending 24hrs whereas with higher amount of hydrophilic polymer drug release occurred less than above. Drug-polymer interactions were studied by FTIR spectroscopy and surface morphologies of the films were investigated using SEM