Formulation and Evaluation of Controlled Release Microspheres Containing Metformin Hydrochloride

Metformin hydrochloride (MH) is an oral hypoglycemic agent widely used in the treatment of type II (non insulin dependent) diabetes mellitus. The objective of this work was to assess the effect of drug and polymer ratio and release of MH from hydrophilic polymeric matrices. Controlled release microspheres of MH were formulating using a hydrophilic swellable polymer HPMC and Carbopol separately. Controlled release microsphere of MH was prepared by Emulsification heat Stabilizing method. These microspheres were further evaluated for drug-polymer ratio, percentage yield, arithmetic mean size, percentage entrapment efficiency, scanning electron microscopy, angle of repose and in-vitro release. HPMC and carbopol act as viscosity enhancing agent for Prolong action with increased Drug release without loosing its therapeutic activity.