Preparation, Numerical Optimization and Evaluation of Ciprofloxacin PLGA and PLA Nanoparticles by Solvent Displacement Technique

The aim of the current study to prepare and characterization of drug as a nanoparticles by numerical optimization method by using ciprofloxacin as a model drug and using Ploy (Lactic –co-glycolic acid) PLGA and (Poly lactic acid) PLA. The particles were prepared by solvent displacement technique. The formulations were evaluated in terms of surface character, Particle size, drug loading efficacy and separation of free drug. The mean diameter was dependent on Polymer concentration.