1Department of Pharmaceutics, Shree Santkrupa College of Pharmacy, A/P Ghogaon, Tal. Karad, Dist. Satara. Maharashtra, 415111
2Department of Pharmaceutics, University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa
*Corresponding Author E-mail: sachinpatil79@rediffmail.com
Direct tabletting technique has been widely used successfully for various drugs. But it strongly depends upon the quality of the crystals used. Crystals could be generated employing any of the available techniques like sublimation, solvent evaporation, vapor diffusion, thermal treatment and crystallization from melt precipitation by change in pH, growth in presence of additives or the grinding. Thus the novel agglomeration technique that transforms crystals themselves directly into a compacted spherical form during crystallization process has been desired. The use of spherical crystallization as a technique appears to be efficient alternative for obtaining suitable particles for direct compression. Spherical crystallization is a particle design technique, by which crystallization and agglomeration can be carried out simultaneously in one step and which has been successfully utilized for improvement of flowability and compactability of crystalline drugs.
Direct tablet technique, spherical crystallization, flowability, compactability
