Simultaneous Estimation of Ramipril and Amlodipine by UV Spectrophotometric Method

A new, simple, rapid and novel spectrophotometric method has been developed for simultaneous estimation of Ramipril and Amlodipine. For this, simultaneous equation method is used. The method involved measurement of absorbance at two wavelengths, 210 nm and 238 nm, λ max of Ramipril and Amlodipine respectively. Beer's law obeyed in concentration range of 15–35 μg/mL and 5–25 μg/mL for Ramipril and Amlodipine respectively. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction. This paper describes the development and validation of UV spectroscopic method for Simultaneous estimation of Ramipril and Amlodipine in combined solid dosage form.