Preparation and Evaluation of Rifabutin Loaded Polymeric Microspheres

Present study was designed to investigate the effect of various processing parameters on the physical characteristics of the rifabutin (RFB) microspheres prepared by emulsion solvent diffusion using EC and EC/HPMC polymers. XRD and DSC studies were performed to determine its crystallinity. At the end of 8 hrs, more than 90% of the drug was released by EC/HPMC microspheres; however from EC microspheres only 88% of the drug was released after of 12 hrs. Particle size and spherical shape of the microspheres were confirmed by SEM photomicrographs. Microspheres were found to be stable and non-hygroscopic at accelerated conditions of temperature and humidity.