Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2009
  • Volume: 2
  • Issue: 3

Validated Spectroscopic Method for Estimation of Sumatriptan succinate in Pure and from Tablet Formulation

  • Author:
  • A. Elphine Prabahar1,, R. Kalaichelvi2, B. Thangabalan1, R. Karthikeyan1, Ch. Prabhakar3, P. Vijayaraj Kumar4
  • Total Page Count: 3
  • Page Number: 495 to 497

1Department of Pharmacy, Donbosco PG College, Vetticherukuru Mandal, Guntur 522 017, India

2K.C.Reddy Institute of Pharmaceutical Sciences, Jangamguntla Palem, Medikonduru Mandal, Guntur 522 348, India

3Nova College of Pharmacy, Jangareddygudem, W. G. Dist. (AP), India

4Bharat Institute of Pharmacy, Mangalpally Village, Ibrahimpatnam. RR Dist.-501506, India

*Corresponding Author E-mail: elphine_tafhy26@yahoo.co.in

Online published on 8 April, 2013.

Abstract

Sumatriptan succinate (sumatriptan) is a 5HT1D-Serotonin receptor agonist which is used to treat migraine and it has good vasoconstrictor properties. Only HPLC methods are available for analysis of the same but they are expensive. There is no UV method is available. Here we have developed a new, precise and simple UV spectrophotometric method for estimation of sumatriptan from tablet formulation. The drug obeyed the Beer's law and showed good correlation. It showed absorption maxima at 220 nm; double distlled water. The linearity was observed between 1 – 12 mcg/ml. The results of analysis were validated by recovery studies. The recovery was more than 99%. The method was found to be simple, accurate, precise, economical and robust.

Keywords

Sumatriptan, UV–Vis Spectrophotometry, Migraine, Validation