Antinociceptive Effect of Abutilon indicum Linn Leaf extract

Abutilon indicum Linn (Sweet) (Malvaceae) leaves were extracted with water and evaluated for its antinociceptive effects by employing various models such as acetic acid-induced writhing test, tail immersion test, hotplate method and formalin-induced nociceptive test. The extract at 200 and 400 mg/kg concentration significantly (p<0.01) reduced the number of writhes produced by acetic acid (0.6%) and significantly increased the reaction time in thermal models such as hot water tail immersion, hot plate method and formalin-induced test in a dose dependent manner (p<0.01). Morphine (7.5 mg/kg) and Indomethacin (10 mg/kg) were employed as the standard drugs for comparison. The results of the present study revealed that the aqueous extract of leaves of Abutilon indicum exhibits a potential analgesic effect, which may be mediated by both central and peripheral mechanisms.