*Corresponding Author E-mail: udshivhare@gmail.com
Metformin hydrochloride, an orally administered drug used to lower blood glucose level in patients with non-insulin dependent diabetes mellitus (NIDDM). Its plasma half-life is relatively short and requires frequent dosing. With this view, metformin hydrochloride microcapsules were prepared using hydrophobic polymers i.e. Eudragit S100, ethylcellulose, cellulose acetate by o/o solvent evaporation technique. Different batches of microcapsules were prepared by altering the drug: polymer ratio. Best optimized formula was evaluated for its drug polymer interaction by IR spectra, X-ray diffraction for any polymorphic changes. Scanning electron microscopy indicated that microcapsules prepared were discrete spherical and covered with continuous coating.
