Simultaneous Spectrophotometric Methods for Estimation of Cefixime and Erdosteine in Synthetic Mixture

Two simple, rapid, accurate and economical methods have been developed for the estimation of Cefixime and Erdosteine in synthetic mixture. First method is based on solving the simultaneous equation for the two drugs and second method is based on multicomponent analysis. Cefixime has absorbance maxima at 289.0 nm and Erdosteine at 235.0 nm using methanol as solvent for both methods. The Beer Lambert range was observed in concentration range of 10–50 μg/ml for both Cefixime and Erdosteine. The results of both methods have been statistically validated and found to be satisfactory. The recovery studies confirmed the accuracy of the proposed methods.