Spectrophotometric Methods for the Determination of Etoricoxib in Pharmaceutical Formulations

Simple UV and first derivative spectrophotometric methods have been developed for the determination of etoricoxib in tablet dosage form. In simple UV method, spectrum of etoricoxib in 0.1 N HCl showed absorbance maximum at 271.6 nm, where as in first derivative spectrum it shows maxima at 265.2 nm and minima at 301.6 nm. Beer's law is obeyed over the concentration range 1–25μg/ml. The developed methods have been successfully applied for the determination of etoricoxib in tablet dosage form. The results obtained by the proposed methods were validated by recovery studies.