Nasal Absorption of Drugs – Barriers and Solutions

The large surface area of the nasal mucosa offers a rapid onset of therapeutic effect, potential for direct to central nervous system delivery; no first pass metabolism and non invasiveness all of these maximize patient convenience, comfort and compliance. Interest in intranasal administration as a non invasive route of drug delivery continues to grow rapidly. Although there is an increasing need to identify novel approaches by which to improve the efficacy of drug transport from nasal cavity. For this, it is necessary to know about the mechanism of the nasal absorption, factors affecting absorption and what are the strategies that will help to improve the nasal absorption of the drug.