Natural Gums as Matrix and Coating Material for Colon Specific Drug Delivery

Colon specific matrix and coated tablet of 5-amino salicylic acid were formulated using biodegradable natural gums, Guar gum and Xanthan gum. The drug release behavior of fabricated tablets was investigated. Colon specific matrix tablet containing 200mg of 5-amino salicylic acid using different drug gum ratio of guar gum and Xanthan gum were prepared by wet granulation method. Formulations were optimized on the basis of acceptable tablet properties like hardness, friability, weight uniformity and in vitro drug release. In vitro dissolution studies were done in presence of fresh human feces for microbial degradation of gums. Results of in vitro dissolution studies indicated that matrix tablet containing 20% guar gum was most successful showing better drug release profile. Xanthan gum when combined with guar gum further retards drug release.