Formulation and Evaluation of the Suspending Properties of Leucaena latisiliqua Gum on Acetaminophen Suspension

A pharmaceutical suspension, like other disperse systems, is thermodynamically unstable and therefore it is necessary to include in the dosage form, a stabilizer or suspending agent which reduces the rate of settling and permits easy to redispersion of any settled particulate matter both by protective colloidal action and by increasing the consistency of the suspending medium. Natural gum collected from dried pods of Leucaena latisiliqua, and using as a suspending agent at different concentration in acetaminophen suspension. Different evaluation tests were carried out and reported. Due to high viscosity of Leucaena latisiliqua gum had the strongest suspending ability, (the suspending ability of all the materials was found to be in the order: Leucaena latisiliqua > compound tragacanth gum > acacia gum and act as a stabilizer. It can also serve as a good thickening agent as compared to other materials.