Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2009
  • Volume: 2
  • Issue: 4

A Validated RP-HPLC Method for Simultaneous Determination of Ramipril and Valsartan in Pharmaceutical Formulation

  • Author:
  • Shradhanjali M Singh, Kirti S Topagi, Mrinalini C Damle
  • Total Page Count: 4
  • Page Number: 749 to 752

Dep. of Pharmaceutical Chemistry, A.I.S.S.M.S. College of Pharmacy, Kennedy Road, Near R.T.O., Pune – 411001

*Corresponding Author E-mail: mcdamle@rediffmail.com

Online published on 8 April, 2013.

Abstract

A simple, fast, accurate and precise method has been developed for the simultaneous determination of Ramipril and Valsartan from pharmaceutical formulation by reverse phase high performance liquid chromatography (RP-HPLC). The separation was carried out on Hypersil gold CN column using Acetonitrile and Water [pH adjusted to 3.0 with Orthophosphoric acid (0.08%)] in the ratio (70:30v/v). The retention times of Ramipril and Valsartan were 5.08 ± 0.02 and 3.68 ± 0.02 minutes respectively. The developed method was validated as per ICH Guidelines.

Keywords

Ramipril, Valsartan, RP-HPLC, Validation