Comparative Studies of Release of Ambroxol Hydrochloride from It's Gum Based Matrices

The purpose of this research was to formulate matrices of Ambroxol hydrochloride with natural gums like Xanthan gum and κ-Carrageenan gum and their combinations in different ratios to develop a sustained release dosage form. Various parameters were evaluated such as their physical tests like hardness, thickness, friability. A comparative study was done on the release from various gum matrices. The matrix swelling was studied in pH 6.8 phosphate buffer. Xanthan gum, κ-Carrageenan and guar gum retarded the drug's release when used individually. It can thus be concluded from the studies that natural gums can be effectively used for oral sustained release dosage form.