An increasing number of newly developed drugs are poorly soluble, in many cases drugs are poorly soluble in both aqueous and organic media excluding the traditional approaches to overcoming such solubility factors and resulting in bioavailability problem. An alternative and promising approach is the production of drug nanoparticles (nanosuspensions) to overcome these problems. Techniques such as media milling and high pressure homogenization have been used commercially for producing nanosuspensions. Nanosuspension can be delivered by various routes such as oral, parenteral, pulmonary and ocular system. It also possible to convert nanosuspension to patient-acceptable dosage forms like tablet, capsule and lyophilized powder products. The present review focuses on various manufacturing and formulation perspectives and application of nanosuspension as drug delivery system.
Homogenization, bioavailability, lyophilization, nanosuspension
