Validated Method for the Quantification of Sodium Azide in a Range of ‘Sartan’ Drugs by Ion Chromatography

Sodium azide is harmful to our body organs specially heart and brain, because heart and brain use a lot of oxygen, Sodium azide prevents the cells of the body from using oxygen. For the determination of content of free Sodium azide in a range of sartan drug, a method has been developed and validated on Ion Chromatograph (IC). Strongly basic anion exchange resin column (250 x 4.0) mm is used with 50 x 4.0 mm guard column of same stationary phase. Mobile phase consisted of 2.8 ml of Sulphuric acid per litre of water. The method is validated for its Specificity, Precision, Accuracy, Linearity Ruggedness and Robustness. Sodium azide (as azide) is linear from 0.082μg/ml to 0.61 μg/ml, with Correlation Coefficient 0.99933. Limit of quantitation of the method is 0.082 μg/ml and Limit of Detection is 0.041 μg/ml.