1Department of Pharmaceutical Sciences, Gurusar Sadhar, Ludhiana (Punjab)
2Govt. Institute of Pharmaceutical and Engineering Sciences, Amritsar (Punjab)
*Corresponding Author E-mail: asrpreet2007@rediffmail.com
Online published on 3 April, 2013.
The present study was designed to investigate the analgesic effects of fruits of Silybum marianum L. Gaertn. The ethylacetate and ethanol extracts of Silybum marianum L. Gaertn fruits showed dose-dependent and significant (P<0.05) increase in pain threshold in tail–immersion test. Moreover, both the extracts (100-200mg/kg) exhibits a dose–dependent inhibition of writhing and also showed a significant (P<0.001) inhibition of both phases of formalin pain test. The phytochemical screening of the extract showed the presence of flavonolignans, flavonoids, fixed oils and proteins.
Analgesic activity, Formalin pain test, Tail immersion test, Silybum marianum
