Research Journal of Pharmacy and Technology

SCOPUS
  • Year: 2010
  • Volume: 3
  • Issue: 1

Analgesic Effects of Fruits of Silybum marianum L. Gaertn

  • Author:
  • Manpreet Kaur1,, Harinder Kaur2
  • Total Page Count: 3
  • DOI:
  • Page Number: 92 to 94

1Department of Pharmaceutical Sciences, Gurusar Sadhar, Ludhiana (Punjab)

2Govt. Institute of Pharmaceutical and Engineering Sciences, Amritsar (Punjab)

Abstract

The present study was designed to investigate the analgesic effects of fruits of Silybum marianum L. Gaertn. The ethylacetate and ethanol extracts of Silybum marianum L. Gaertn fruits showed dose-dependent and significant (P<0.05) increase in pain threshold in tail–immersion test. Moreover, both the extracts (100-200mg/kg) exhibits a dose–dependent inhibition of writhing and also showed a significant (P<0.001) inhibition of both phases of formalin pain test. The phytochemical screening of the extract showed the presence of flavonolignans, flavonoids, fixed oils and proteins.

Keywords

Analgesic activity, Formalin pain test, Tail immersion test, Silybum marianum