The Analgesic Effect of Leucas aspera (Wild) Link Extract in Experimental Mice

Leucas aspera(Wild.)Link (Lamiaceae) is a plant used in traditional medicine for various disorders. The aim of this work was to evaluate the antinociceptive activity of the aqueous extract of Leucas aspera in animal models. In the acetic acid induced writhing model, the extract at a dose of 200 and 400 mg kg ⁻¹ body weight showed significant (p<0.01) inhibition of writhing response of 52.63 and 64.35% respectively. In the hot plate test the extract produced a significant (p<0.01) increase in the latency in a dose related manner. This study established the analgesic properties of Leucas aspera (Wild.) Link.