Synthesis and Antimicrobial Evaluation of Some 2-(Piperazinomethylamino) Imidazole Derivatives

Benzoin was reacted with aminomethamine in ethanol to yield 2-amino-4,5-diphenylimidazole, which on further reaction with dichloromethane in presence of ethanolic potassium hydroxide yielded 2-(chloromethylamino)-4,5-diphenylimidazole. The 2-(chlormethylamino)-4,5-diphenylimdazole was reacted with piperazine and its derivatives, which yielded 2-(piperazinomethylamino)-4,5-diphenylimiazole and its respective derivatives. All the compounds were characterized on the basis of IR and ¹HNMR spectral data were screened for antimicrobial activity.