Synthesis of 2-Substituted Pyrimidines and Evaluation of Its Pharmacological Activities

It is the continuation of our search for new substituted pyrimidines based on analgesic, CNS depressant sedative and hypnotic activity. A mixture of acetanilide, aromatic aldehyde in ethanol, Sodium hydroxide to give (Compound-I) N-phenyl 3-phenyl-2-propenamide. Compound-I on reaction with ethanol, Sodium hydroxide, urea to give (Compound-II) 6-phenyl amino-4phenyl-2-hydroxy pyrimidine. The compound-I react with Sodium hydroxide, thiourea, ethanol to give (Compound-III) 6-phenyl amino 4-phenyl-2-mercapto pyrimidine. The synthesized compounds were evaluated for their analgesic and depressant activities compared to Diclofenac and Diazepam as positive control. Detailed synthesis, spectroscopic and toxicity data were studied and reported.