As patient with acute Acidity and ulcer have markedly reduced functional ability and are extremely restless. In such cases rapid onset of action is of prime importance, so the patient would be benefited by using proposed drug delivery system which may help them to return to normal state and resume their functional activity quickly assuming rapid and increased pregastric absorption. In the present work, The Mouth dissolving tablets (MDT) of Ranitidine were prepared by Direct compression using Kollidon, L-HPMC and L-HPC in different concentration like 10%, 15% and 20% and evaluated for hardness, friability, disintegration time and in-vitro dissolution study. The results indicate that MDT containing L-HPC in 20% showed desired drug release profile (> 99% in 4min) and gives the disintegration in 40 sec and release rate of these variation of super disintegrating agents is found in manner; L-HPC> Kollidon > L-HPMC in proportion 10<15<20.
Ranitidine HCl, L-HPC, Kollidon, L-HPMC, Mouth dissolving tablet
