Simultaneous Estimation of Aceclofenac and Paracetamol in Solid Dosage Form by UV Spectrophotometry

Aceclofenac is a non steroidal anti-inflammatory drug and paracetamol is an analgesic and antipyretic drug. Simple, precise, rapid and selective simultaneous equation and Q-analysis UV spectrophotometric methods have been developed for the simultaneous determination of aceclofenac and paracetamol from combined tablet dosage forms. The methods involve solving of simultaneous equations and Q-value analysis based on measurement absorptivity at 274nm, 267.5nm and 245 nm respectively. The method shows good linearity, accuracy and reproducibility. Results of analysis validated statistically and by recovery studies.