Simultaneous Determination of Cefuroxime Axetil and Potassium Clavulanate in Tablet Dosage Form by Spectrophotometry

Two accurate, precise, sensitive and economical procedures for simultaneous estimation of Cefuroxime Axetil and Potassium clavulanate in tablet dosage form have been developed. The methods employed were Absorbance correction method (I) and first order derivative spectroscopic method (II). The first method employs wavelength 277 nm for direct estimation of Cefuroxime axetil where Potassium clavulanate shows nil absorbance. Estimation of Potassium clavulanate is carried out after correction for absorbance of Cefuroxime axetil at 218 nm. The second method is based on first order derivative spectroscopy. Wavelengths 230 nm and 300 nm were selected for the estimation of the Potassium clavulanate and Cefuroxime axetil respectively. Both the drugs obey Beer's law in the concentration range 5–50 mcg/mL. The results of analysis have been validated statistically and by recovery studies.