Protein and Peptide drugs are increasingly recognized as potential leads for the development of new therapeutics for a variety of human ailments. With the advent of new technologies and radical growth in the field of biotechnology, dozens of protein and peptide drugs have been marketed. The unique requirement of peptides and proteins in designing delivery system and the unprecedented recent growth in the field has driven a great deal of research into novel means of drug delivery. The search for approaches that provide formulations that are stable, bioavailable, readily manufacturable and acceptable to the patient, has led to major advances in development of oral, transdermal, transmucosal and controlled released technology, as injectable administration, can result in low patient compliance. Hence, there is a drive in the biotechnology industry to produce needle-free and more user-friendly drugs This review focuses on the challenges and approaches involved in the delivery of these biomolecules through non-invasive routes.
Protein, peptide, oral, Pulmonary and Transdermal
