1National Institute of Ayurvedic Pharmaceutical Research, Patiala, India
2Govt. Polytechnic College for Girls, Patiala, India
3Akal College of Pharmacy and Technical Education, Mastuana Sahib, Sangrur, India
*Corresponding Author E-mail: vikas_4308@rediffmail.com
Online published on 3 April, 2013.
The present study was designed to evaluate both anti-inflammatory and antinociceptive activity of the ethanolic extract of dried leaves of Adiantum capillus (ACEE), using the Carrageenan-induced paw edema method in rats and Tail-flick method in mice, respectively, at various dose levels. The maximum anti-inflammatory effect of the extract was found to be at 300 mg/kg in carrageenan test and this effect was equivalent to phenylbutazone (PBZ) (80 mg/kg, orally) (p<0.05). The extract also demonstrated marked antinociceptive activity at a dose of 300 mg/kg and the effect was comparable to that of standard drug, Ibuprofen (100 mg/kg orally) (p<0.05). The results of this study have established the anti-inflammatory activity and antinociceptive activity of leaf extracts of Adiantum capillus.
Adiantum capillus, Paw edema method, Adiantaceae, Tail-flick method
