Design and Evaluation of Floating Drug Delivery System of Furosemide

Controlled release gastroretentive dosage forms enable controlled and continuous input of the drug to the upper parts of gastrointestinal tract and improve the bioavailability of drug that is characterized by narrow absorption window. Floating drug delivery systems of furosemide were formulated using various concentrations of polymers such as HPMC K4M,HPMC K15M,HPMC K100M,ethyl cellulose and effervescing agents sodium bicarbonate and citric acid. The formulations were evaluated for floating properties and in vitro drug release studies. The floating tablets fulfilled the official specifications of weight variation, hardness, friability and drug content. The formulated tablets showed controlled release of the drug for a period of 10 hrs. The drug release from the floating tablets was found to be non fickian diffusion obeying zero order kinetics.