Formulation and Evaluation of Lacidipine Tablets Employing Lacidipine – Starch Phosphate Binary Systems

The objective of the study is to formulate and evaluate lacidipine tablets employing lacidipine-starch phosphate binary systems. Binary systems of lacidipine in starch phosphate were prepared in different drug to carrier ratios. Lacidipine tablets were formulated employing lacidipine-starch phosphate binary systems and their corresponding physical mixtures. The compressed tablets were evaluated for various tablet characteristics including dissolution rate and efficiency. Marked increase in the dissolution rate and efficiency of lacidipine was observed with tablets of binary systems in comparison to tablets formulated with physical mixture and pure drug. Dissolution of lacidipine from the binary systems obeyed first order kinetics.