Formulation and Evaluation of Loperamide Hydrochloride Mouth Dissolving Tablet by Using Super Disintegrants

Loperamide hydrochloride 180 mg mouth dissolving tablet was prepared by using super disintegrants such as Sodium starch glycolate, Croscarmellose Sodium, Crospovidone at various concentration and Sucralose, aspartame used as sweetening agent. The excipients were used for this study was based on the compatibility studies. All the formulations were prepared by direct compression method. Among all the formulations Crospovidone at 10 mg/tablet gives 98% drug release at 12^th minute by UV method. It was considered as optimized batch. The optimized batch was passes all the evaluation parameters and stability studies.The final formulation were packed in blister package.