Research Journal of Pharmacy and Technology

Amoxicillin trihydrate is a β-lactam antibiotic, widely recommended for management of H. pylori infection. Due to its frequent dosage regimen (TDS; 7 days), it has poor patient compliance. The present study aims to reduce the dosing frequency by using single and combinations of synthetic and natural polymers for preparation of mucoadhesive tablets. Various approaches to combine synthetic (HPMC-K4M, SCMC and sodium alginate) and natural (tragacanth and acacia) hydrophilic polymers have been made to prepare total eight formulations. Further, these formulations were subjected to different evaluation studies like friability, content uniformity, surface pH, wash-off and dissolution tests. All the tests were performed using standard methods. Results for in vitro drug release and wash-off studies suggest that the formulation (FHT) containing HPMC-K4M and tragacanth has shown better mucoadhesive property. Other studies have shown satisfactory results in all eight formulations. Thus, the present investigation suggests the combination of HPMC-K4M and tragacanth, as hydrophilic polymers for preparation of amoxicillin trihydrate mucoadhesive tablets.