Formulation and Optimization of Orodispersible Tablets of Olanzapine

In the present study, fast dissolving tablets of Olanzapine were prepared by Roll compaction technique with a view to enhance patient compliance. Six formulations were prepared for the optimization of concentrations of disintegrant and binder. The formulations were developed with the aim of having balance over the hardness and disintegration time of the tablets. The prepared batches of tablets were evaluated for hardness, friability, thickness and disintegration time. Based on in vitro dispersion formulations were tested for the in vitro drug release pattern in 0.1 N Hcl. The formulations were checked for their stability at 40°/75% relative humidity for 6 months. Among the formulations prepared F-5 emerged as the overall best formulation.The drug release was found to be comparable to the marketed formulation. Short term stability studies on the formulations indicated that there was no change in drug content and invitro dispersion time.