Research Journal of Pharmacy and Technology

SCOPUS
  • Year: 2010
  • Volume: 3
  • Issue: 2

A Validated HPTLC Method for Simultaneous Determination of Losartan and Perindopril in Tablets

  • Author:
  • KS Lakshmi, Lakshmi Sivasubramanian, Ajit Kumar Pandey
  • Total Page Count: 3
  • DOI:
  • Page Number: 559 to 561

Dept. of Pharmaceutical Analysis, SRM College of Pharmacy, SRM University, Kattankulathur-603 203, (T.N.)

*Corresponding Author E-mail: lakshmiss@hotmail.com

Online published on 3 April, 2013.

Abstract

A Simple, fast and precise high performance thin layer chromatographic method has been developed for the simultaneous determination of losartan and perindopril in tablet. Separation was carried out on precoated TLC plates, coated with silica gel 60 F 254. The separation was done using a mobile phase toluene: acetonitrile: formic acid (5:5:0.3 v/v/v). After development, the chromatoplates were scanned at 215 nm. The Rf value of losartan and perindopril was found to be 0.55 and 0.27 respectively. The results of the analysis have been validated statistically and by recovery studies.