Characterization and Solubility Enhancement of Etoricoxib in Solid Dispersion Systems Using Lipid Carriers Gelucire 44/14

The present study was aim to investigate on solid dispersion of etoricoxib using Gelucire44/14, PEG4000 prepared by co-evaporation and direct filling method were characterized by phase solubility study, in-vitro dissolution, HSM, XRD, stability studies. HSM have demonstrated the ability of melted Gelucire44/14 to dissolve the crystal of etoricoxib at increasing temperatures. In The XRD pattern of pure etoricoxib showed numerous distinctive peaks while Solid dispersion showed all the peaks shown by the drug however intensity of the peaks found was markedly reduced and d-spacing increases. Phase solubility study indicated the drug solubility increased linearly with increase in polymer concentration. In-vitro drug dissolution shows maximum drug release up to 99.84% from solid dispersion prepared by co-evaporation method.