Simultaneous Estimation of Metoprolol and Atorvastatin in Combined Dosage Form

Three novel, simple, sensitive, economical, accurate, rapid and precise spectrophotometric methods have been developed for the simultaneous estimation of Metoprolol and Atorvastatin in pharmaceutical oral solid dosage form. Method A involves solving of simultaneous equations based on measurement of absorbance at two wavelengths 223nm and 241nm, λmax of metoprolol and atorvastatin respectively. Method B involves estimation by Absorbance ratio method at 231 nm (iso absorptive point) and at 241 nm (λmax of atorvastatin). Method C involves AUC for the normal spectrum. All the methods utilize methanol as solvent. Beer's law was obeyed in the concentration range of 5–90 μg/mL for both the drugs and the linearity was established. The results of analysis have been validated statistically and by recovery studies. The proposed methods can be successfully applied for the estimation of metoprolol and atorvastatin in combined dosage form.