Formulation and Evaluation of Ranitidine Hydrochloride Mouth Dissolving Tablet by Effervescent Formulation Technique.

Mouth dissolving tablet constitute an innovative dosage form that overcome the problem of swallowing and provides a quick onset of action thus proves to be a user friendly formulation. In view to increase patient compliance and to enhance the bioavailability an attempt was made in the present study to formulate six formulations using two effervescent agents in different concentrations. Sodium bicarbonate and citric acid were used as effervescent agents. Sucralose was employed to mask the bitter taste and orange flavour to impart palatability. All the prepared formulations were evaluated for both precompression and post compression parameters. The study revealed that effervescent formulation approach released about 90% of the drug at the end of 25minutes respectively. The disintegration time for all formulations ranged from 15 to 20 seconds and gave soothing fizz, with excellent mouth feel and good palatability.