Research Journal of Pharmacy and Technology

SCOPUS
  • Year: 2010
  • Volume: 3
  • Issue: 2

Microwave Mediated Synthesis and Antifungal Activity of Some 5-Benzylidene-2, 4-thiazolidinediones

  • Author:
  • M. Srinivas1, K. Satyanarayana1,, S. Kiran Kumar2, N. Sravan Kumar2, V. Ajay2, N. Kishore2
  • Total Page Count: 3
  • DOI:
  • Page Number: 619 to 621

1Department of Medicinal Chemistry, Mother Teresa College of Pharmacy, Ghatkesar, R.R. Dist., A.P, India

2Department of Medicinal Chemistry, Nagarjuna University, Guntur, A.P, India

*Corresponding Author E-mail: rajshaz@gmail.com; srinu_629@yahoo.co.in

Online published on 3 April, 2013.

Abstract

A series of 5-benzylidene-2,4-thiazolidinedione derivatives were synthesized by employing microwave irradiation. The synthesis involves microwave irradiation of an aromatic aldehyde with 2,4-thiazolidinedione in sodium acetate/acetic acid in ethanol. The reaction was completed in 15–30 min with 68–82% yields and was environmentally friendly with easy workup. The synthesized compounds were evaluated for antifungal activity.