Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2010
  • Volume: 3
  • Issue: 3

Anti-inflammatory, Analgesic and Antimicrobial Activity of Some Novel Schiff's bases of N-aryl anthranilic acid Derivatives

  • Author:
  • P. Muthumani1,, R. Meera1, S. Venkataraman1, Murugan 1, N. Chidambaranathan2, P. Devi3, B. Kameswari4, B. Eswarapriya5
  • Total Page Count: 4
  • Page Number: 740 to 743

1Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Uthangudi, Madurai -625107, Tamilnadu, India

2Department of Pharmacology, K. M. College of Pharmacy, Uthangudi, Madurai -625107, Tamilnadu, India

3Department of Pharmacognosy, K. M. College of Pharmacy, Uthangudi, Madurai -625107, Tamilnadu, India

4Department of Biochemistry, K. M. College of Pharmacy, Uthangudi, Madurai -625107, Tamilnadu, India

5Department of Biotechnology, St. Michael College of Engineering, Sivagangi, Tamilnadu, India

*Corresponding Author E-mail: meeraharsa@yahoo.com

Online published on 3 April, 2013.

Abstract

Para substituted N-aryl anthranilic acid derivatives were synthesized via Ullmann condensation of o-Chlorobenzoic acid with various p-substituted aniline in the presence of cupric oxide (catalyst) and anhydrous potassium carbonate (for removal of hydrogen halide formed during reaction). The synthesized compounds (Ia-Ih) were evaluated the following biological activities Anti-inflammatory, Analgesic activity, Anti-bacterial activity. Organism used: Staphylococcus aureus (MTCC 96) Klebsiella aerogenes (MTCC), E. Coli (MTCC 722) Standard Used: Oflaxacin (10μg/disc)

Keywords

N-aryl anthranilic acid derivative, Anti inflammatory, Analgesic, Anti bacterial