Antinociceptive, Anti-inflammatory activity of Coriander sativum Leaves

The chloroform extract of the leaves of Coriander sativum Linn (Umbelliferae) was investigated for the possible antinociceptive activity in mice and anti-inflammatory effect in rats. The antinociceptive effect of the extract was carried out using two models. The hot plate method, Acetic acid induced writhing method in mice. The antiinflammatory effect was investigated employing the carrageenan induced paw oedema in rats. Results of the study revealed that the inhibitions of acetic acid induced abdominal constrictions were observed at the i.p. doses of 100 mg/kg (66.7%) 150 mg/kg (84.0%) and 200 mg/kg (98.4%) compared to control. In hot plate method the extract exhibited significant (p<0.001) antinociceptive effect at the dose level of 200 mg/kg i.p in mice. The same extract also exhibited anti-inflammatory effects which were found to be significant (p<0.001) at the dose level of 200 mg/kg p.o. in rats.