Effect of Hydrophilic and Hydrophobic Polymers on the Release of Naproxen from Sustained Release Tablets.

The purpose of this research was to formulate sustained release tablets matrices of Naproxen with hydrophilic and hydrophobic polymers like Sodium alginate, Xanthan gum and Ethyl cellulose and their combinations in different ratios.

Matrix tablets were formulated using polymers like Sodium alginate, Xanthan gum and Ethyl cellulose and their combinations at different ratios. The effect on release profiles and matrix swelling in phosphate buffer pH 7.4 was studied and treated with release kinetic models. Accelerated stability studies were conducted as per ICH Guidelines at 40°C/75% RH for 6 months. Sodium alginate and Xanthan gum retarded the drug release more than Ethyl cellulose. It can be concluded that that hydrophilic polymers compared to hydrophobic polymers can be effectively used for oral sustained release dosage form.