Antiulcer Activity of Methanolic Extract of Cassia angustifolia Bark and Its Comparison with Ranitidine in Shay Rat.

Methanolic extract of Cassia angustifolia bark was tested for its anti gastric ulcer and compared with anti ulcer of ranitidine in shay rat model. Oral dose with 5mg/kg body weight of ranitidine showed complete absence of ulceration in shay rats. The anti gastric ulcer activity of Cassia angustifolia Methanolic extract (800mg/kg) body weight was found equal to the effect produced by 5mg/kg Ranitidine in this model. Oral administration of methanol extract (800 Mg./Kg) Cassia angustifolia bark showed complete inhibition of ulceration and significant reduction in free acidity, Total acidity peptic activity and volume of gastric juice secreted were found.