1Department ofPharmaceutical Chemistry, K.L.E. University's College of Pharmacy, J.N.M.C. Campus, Belgaum-590010, India
2Department of Pharmaceutics, K.L.E. University, J.N.M.C. Campus, Belgaum-590010, India
3Deparment of pharmacology, K.L.E. University, J.N.M.C. Campus, Belgaum-590010, India
4Smt. S. S. Patil Institute of Pharmacy, Chopda-425107, Jalgaon, India
In the present work, mouth dissolving tablets of domperidone were design with a view to enhance the patient compliance and provide a quick onset of action. Domperidone is antiemetic dopamine receptor antagonist and it has long half life. The purpose of this study mouth dissolving tablets rapidly disintegrate in oral cavity and increase the dissolution so that the drug attains the therapeutic level in short time, so elicits better pharmacological effects. Mouth dissolving tablets prepared by direct compression and using super disintegrants like sodium starch glycolate, croscarmellose sodium and crospovidone in different concentration and evaluated for the pre-compression parameters such as bulk density, compressibility, angle of repose etc. The prepared batches of tablets were evaluated for hardness, weight variation, friability, drug content, disintegration time and in-vitro dissolution profile and found satisfactory. Among all, the formulation containing 5%w/w superdisintegrant crospovidone was considered to be best formulation, which release up to 98.15% in 15min.
Domperidone, Mouth dissolving tablet, superdisintegrants, Dissolution rate
