1Department of Diagnostic Microbiology, Doctors’ Diagnostic Centre, Tiruchirappalli-620 018
2P.G. and Research Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College, (Autonomous), Poondi, 613 503, Thanjavur District, Tamil Nadu. India
3Dept. of Microbiology, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, India
*Corresponding Author E-mail: suresh.maray@gmail.com
Online published on 3 April, 2013.
Centella asiatica is a small herbaceous annual plant of the family Mackinlayaceae (Apiaceae) and subfamily Mackinlayoideae and is native to India. The ethanolic extract of Centella asiatica was screened against Mycobacterium tuberculosis by microdilution bioassay in L-J (Lowenstein -Jensen) media and Versa-Trek rapid culture system. The leaf extracts showed significant inhibitory activity against Mycobacterium tuberculosis. The both conventional L-J and Versa-Trek rapid culture methodologies were found effective to inhibit the growth of Mycobacterium tuberculosis. The major bioactive compounds in ethanol extract of Centella asiatica were Octadectrienoic acid and n-Hexadecanoic acid by GC-MS analysis.
Medicinal plants, Tuberculosis, Antimycobacterial activity, Mycobacterium tuberculosis
