Research Journal of Pharmacy and Technology

In the present study, an attempt has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance by developing controlled release (CR) tablets of silymarin. The CR tablets of silymarin were prepared by direct compression method. Three formulations containing different concentration of drug and polymer in the ratio of (1:0.25) (1:0.5) and (1:0.75) were prepared. The formulated tablets were compared with the marketed sample. The evaluation tests for powder blends are angle of repose, bulk density, tapped density, compressibility index and hausner's ratio. The powder blend contains good flow character. Tablets were evaluated for various parameters such as thickness, hardness, friability, drug content, weight variation, stability studies and invitro release studies. The proportion of the polymer showed significant difference in the release of the drug.