Effect of Different Superdisintegrant on Drug Release Behavior of Directly Compressible Domperidone Tablet

The aim of this study was to investigate the influence of superdisintegrant on drug release behavior of tablet prepared by direct compression technique. It is demonstrated that the disintegration and dissolution from tablets of poorly soluble, hydrophobic drugs i.e. Domperidone can be strongly improved by incorporation of hydrophilic, strongly swelling carriers like the super disintegrants sodium starch glycolate (SSG) and croscarmellose sodium (CCS), cross povidone (CP), KYRON T 314. As an effect of its lower swelling power, the super disintegrant Sodium Starch Glycolate is far less effective than the other super disintegrants. It was found, however, that tablet containing a too high concentration of the super disintegrant slow down the drug release from tablets. This effect is caused by the formation of a viscous barrier of the super disintegrant in the tablet during the dissolution process.