1Department of Pharmaceutical Chemistry, St. Ann's College of Pharmacy, Nayunipalli Village, Vetapalem Mandal, Chirala, Andhra Pradesh, India-523187
2Department of Pharmaceutical Chemistry, Siddhartha Institute of Pharmaceutical sciences, Jonnalagadda, Narsaraopet, Guntur Dist, Andhra Pradesh, India-522601
3Department of Pharmacy, Annamalai University, Chidambaram-608002, Tamil Nadu
*Corresponding Author E-mail: chennuprasad@gmail.com, chennu_prasad@yahoo.com
Online published on 3 April, 2013.
The non nucleoside reverse transcriptase inhibitor Nevirapine (NEV), formulating sample is analyzed with instruments Infrared spectroscopy (IR), Reverse phase High performance liquid chromatography (RP-HPLC) and Gas chromatography (GC), the type of functional groups present in the NEV sample was analyzed with IR, the concentration of Nevirapine compounds NEV A, B and impurity-1 in the formulating nevirapine sample and the assay of nevirapine was done with HPLC with retention time greater than 5 and presence of residual solvents such as Dichloro methane, Chloroform, Dimethyl formamide, O-xylene was estimated with GC, the loss on drying and residue on ignition as 0.14 and 0.04% w/w respectively.
Nevirapine anhydrous, IR, RP-HPLC, GC
