Analgesic Activity of 2-Hetero Substituted -4-Quinazolinones

Analgesic activity of newly synthesized series of 2-heterosubstituted-4-quinazolones (NN, NP, NC, NNB, NPB, NCB) were studied in mice. The analgesic activity was carried out at healthy male Swiss albino mice by writhing method and tail immersion method. Aspirin (150mg/kg p.o) and pentazocin (10mg/kg i.p) were used as positive controls for writhing and tail immersion method respectively. The synthetic compounds were administered orally in the dose of 30mg/kg, 90mg/kg as 1% CMC suspension. Results indicate that statistically significant reduction was obtained at 30mg dose level for compounds NP, NPB and NC by writhing Method. Their p value less than 0.05.