Spectrophotometric Estimation of Risedronate Sodium in Bulk and Pharmaceutical Formulations using Multivariate Technique

A sensitive, accurate and economical UV spectrophotometric method with multivariate calibration technique for the determination of risedronate sodium in bulk drug and pharmaceutical formulation has been described. This technique is based on the use of the linear regression equations by using relationship between concentration and absorbance at five different wavelengths. The results were treated statistically and were found highly accurate, precise and reproducible. The method is accurate, precise and linear within the range 10–60μg/ml. There was no interference from the excipients. This statistical approach gives optimum results for the eliminating fluctuations coming from instrumental or experimental conditions.