Formulation and Evaluation of Effervescent Floating Tablet of Domperidone Maleate

Domperidone Maleate has peripheral dopamine receptor blocking properties. It is used in the treatment of vomiting. Domperidone Maleate effervescent floating tablets were developed in ten different formulations (B1 to B10) by employing different grades of polymers and effervescent agents such as sodium bicarbonate and citric acid. The formulations were evaluated for various physical parameters, buoyancy studies, dissolution studies, dissolution parameters and drug released mechanisms.B10 formulation showed maximum floating time of 24 hours and gave slow and maximum drug release of Domperidone Maleate spread over 24 hours. Finally the tablet formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.