1National Institute of Miners Health, JNARDC Campus, Wadi, Nagpur-440023 (M.S.) India
2PGTD Department of Biochemistry, LIT Campus, Nagpur-440001 (M.S.) India
3Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441110 (M.S.) India
4Manoharbhai Patel Institute of Pharmacy (B. Pharm.), Kudwa, Gondia -441614 (M.S.) India
*Corresponding Author E-mail: p_k_7995@yahoo.co.in
Online published on 3 April, 2013.
The main objective of the study has been to evaluate Antifertility Activity of methanolic extract of bark of Ficus bengalensis Linn. with special reference to ovarian, vaginal and uterine histoarchitecture of female reproductive system of rats. The study revealed that administration of methanolic extract of bark at a dose of 250 mg/kg body weight, consecutively for 21 days, showed modular histological changes in the structures of ovary and uterus. The ovarian follicle showed structural disparity in the ovarian cells and granulose cells. The follicles were degenerated and dysfunctional. In the uterus, the endometrial glands were mere degenerated and dysfunctional. From this result, the bark extract of Ficus bengalensis would be serving as a tool for birth control.
Antifertility activity, Histoarchitecture changes, Ficus bengalensis, Estrous cycle, female reproductive system
